名词解释:
- high-grade serous ovarian cancers (HGS-OvCas).
- TNBC
卵巢癌 通常分成4类:
- serous (the most frequent)
- endometrioid,
- mucinous
- clear cell
而每一个类别都有low and high级别,所以组合起来就high-grade serous ovarian cancers (HGS-OvCas)最恶性。
而乳腺癌也通常根据分子分型分成4类:
- 管腔A型(ER阳性,PR≥20%,HER2阴性,Ki-67<20%)
- 管腔B型(ER阳性,PR<20%和/或HER2阳性和/或Ki-67≥20%)
- HER2过表达型(ER阴性,PR阴性,HER2阳性)
- 基底样型(ER阴性,PR阴性,HER2阴性)
因为分子分型临床应用还是有一定难度,所以IHC检测结果的TNBC通常是代替基底样型
卵巢癌完整分类
参考: April 2019 https://doi.org/10.1038/s41591-019-0422-6
- borderline tumors (BTs; non-carcinoma) 约占15%
- primarily of serous BT (SBT)
- mucinous BT (MBT) subtypes
- type I (carcinomas)
- low-grade serous (LGS)
- mucinous(MC)
- endometrioid (END)
- clear cell (CCC) carcinomas
- type II tumors (carcinomas)
- high-grade serous (HGS) tumors
HGS的来源:
- fimbria of the fallopian tube (FT)
- surface epithelium (OSE)