【新的合辑】单细胞测序时代的中性粒细胞

2024-05-11 18:01:07 浏览数 (1)

从去年5月开始的孟德尔随机化好像进入了瓶颈期,有一些问题想要沉下心好好思考,因此想把MR的学习转向幕后。接下来的时间里,我会专注于单细胞测序中性粒细胞的文献梳理(前几期会通过综述分享先引入中性粒细胞的“前世今生”),大家有关于MR的问题也欢迎继续在后台q我,我会尽力解答~

以下是后续新的专辑的目录大纲,也非常诚挚地希望大家对这个专辑的方向或者内容提供更多的建议和指导——

顶刊推荐,带你走近中性粒细胞

  1. 中性粒细胞的前世今生
    • The Neutrophil
    • The Neutrophil Life Cycle
    • Heterogeneity of neutrophils
  2. 中性粒细胞不中立??
  • Neutrophil phenotypes and functions in cancer: A consensus statement
  • Neutrophils in cancer: neutral no more
  • Neutrophils in chronic inflammatory diseases
  1. 聚焦肿瘤,中性粒细胞正邪难辨
    • Neutrophil plasticity in the tumor microenvironment
    • Neutrophil diversity and plasticity in tumour progression and therapy
    • Neutrophils as emerging therapeutic targets
    • Neutrophils in cancer: heterogeneous and multifaceted
    • Neutrophils determine immunotherapy success
    • Deterministic reprogramming of neutrophils within tumors
  2. PMN-MDSC,殊途同归
    • Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
    • Myeloid-derived suppressor cells in cancer and cancer therapy
    • Made to order: emergency myelopoiesis and demand-adapted innate immune cell production

单细胞时代,揭开中性粒细胞神秘面纱

本章节以单细胞文献复现为主,每个小节5-7篇文献,如果有新的文献出来也会加更

  1. 正常状态下
  2. 感染与稳态
  3. 肿瘤
  4. 其他

题外话:肿瘤以外,中性粒细胞与其他疾病的恩怨情仇

本章节看看结合孟德尔随机化方法以后的中性粒细胞

  • 孟德尔随机化分析一:Neutrophil counts and cardiovascular disease
  • 孟德尔随机化分析二:White Blood Cells and Blood Pressure: A Mendelian Randomization Study
  • ……

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